Elucidating the role of androgen receptor in breast cancer
Assistant Professor University of California, Irvine, CA, 2007 Over 200,000 new cases of breast cancer are diagnosed in the U. each year, affecting 1 in 8 women in their life-time.
Despite the recent advances in diagnostic tools, breast cancer mortality rate has only declined slowly, justifying the urgent need for a better diagnostic marker for a treatment success.
The Furuta lab has been working to understand the primary cue that drives pre-neoplastic progression of normal breast cells.
A particular interest of her lab is novel secreted products of adipocytes, termed adipokine.
She is involved with all of the COM&LS graduate programs, including the MD/Ph D dual degree program, all of the Ph D and MSBS Biomedical Science Program training tracks, MSBS-Medical Science for premedical students, MSBS-Medical Physics, MSBS-Oral Biology for Dentistry residents, MSBS-Orthopedic Sciences, MSBS-Human Donation Sciences, MSBS-Physician Assistant studies, and MSBS-Assistant in Pathology.
The majority of her time is focused on the Biomedical Science Program research training tracks.
Raf kinase inhibitor protein (RKIP) is a novel metastasis suppressor gene in and its expression is diminished in breast cancer metastases.
Restoring RKIP expression is sufficient to inhibit cancer metastasis in experimental mouse models suggesting RKIP can function alone to regulate metastasis.